Irremediable

The doctor said that this sickness is irremediable.

Source: tatoeba (1115836)

Dryas was almost tempted by this display of friendship and these splendid promises to give his assent to the marriage; but on the other hand he reflected that the girl seemed destined for a higher connection, and he feared that he might find himself in an irremediable difficulty should the maiden ever be identified and her parents learn that he had married her to a man of such low condition, merely for the sake of some presents. For this reason he refused his assent and declined all the gifts, at the same time entreating Dorcon not to be offended.

Source: tatoeba (6212479)

It is not only misery, corruption and Third Worldism that has led the Kabyles to want the independence of Kabylia, but it is the total difference with the other Algerians on all levels, political, mystical, linguistic, philosophical, legal, moral, cultural and civilizational. And this last one is irremediable!

Source: tatoeba (9472752)

The effects may be less dramatic in the short term than the destruction that could be wrought by nuclear explosions, but over the next three to four decades, climate change could cause irremediable harm to the habitats upon which human societies depend for survival.

Source: tatoeba (11739232)