Ranked by relevance and common usage.
Keep "malacia" when the sentence already sounds natural, when a synonym would add unintended emphasis, or when readers need the most familiar wording. A synonym should clarify or sharpen the message, not simply make the sentence look more varied.
If two options seem close, choose the one that best matches the audience and purpose of the sentence.
Choose a synonym only if it keeps the core idea of "malacia" intact in the sentence you are editing.
Check whether the replacement sounds more formal, casual, emotional, technical, or forceful than the original word.
Read the full sentence after the swap. Keep the synonym only when the sentence becomes clearer or more precise.
Review note: Synonym lists are ranked with lexical data and reviewed for practical writing value. Use the comparison notes, sentence evidence, and source labels together; a high-ranking synonym can still be wrong when the audience, register, or grammar changes.
After choosing a replacement for "malacia", read the sentence once for meaning and once for rhythm. The best synonym should feel natural in the full sentence, not only accurate in a word list.
If the synonym makes the sentence slower, vaguer, or more dramatic than intended, keep "malacia" or choose a simpler alternative from the closest-match group.
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2 total sentences available.
As soon, namely, as a process of this sort sets in in a compound organ, as for example, a muscle, a palpable myo-malacia is certainly produced when all the muscular elements at a given point are at once affected; but it happens far more frequently that, in the course of a muscle, only a comparatively small number of primitive fasciculi are affected, whilst the others remain almost intact.
Source: wiktionary
The least abnormal condition appears to be the malacia, or desire for highly spiced or acid foods that are sometimes seen in chlorotic girls and in pregnant women.
Source: wiktionary
Closest matches include brain softening, brain tissue softening, cerebral softening, degeneration, soft tissue degeneration.
Compare the replacement against real sentence context. This entry includes sample sentences so you can check tone, grammar, and meaning before swapping words.