Referendums are snapshots of sentiment at a given point in time. Government by referendum is government by crowd acclamation: not democracy, but ochlocracy. That is exactly why we have representative democracy. If referendums would be a poor way to decide on health and safety, air traffic control, or education, they are an exceedingly poor way to decide a matter as momentous as membership of the EU. This is and should be a matter for Parliament, taking all factors into account.
Source: wiktionary