Systemic diseases are those that affect the entire organism.
Source: tatoeba (2798356)
Systemic
/sɪˈstɛmɪk/
Synonyms for "systemic" (308 found)
Ranked by relevance and common usage.
Closest matches (10)
Adjective(5 words)
agricultural ecosystem balanceagricultural systemsantiblackbiological mechanismbiological systems thinking
Preposition(1 words)
at whole-organism level
Strong matches (15)
Adjective(8 words)
biosystemicbiosystemic approachbodily networksbody-widebody-wide approachbody-wide measurementsbody-wide studycollective behavior
Noun(3 words)
capacity buildingcollective dynamicscommunity structures
Related words (25)
Adjective(11 words)
comprehensiveconstitutionalconstitutional historyconstitutional provisionsconstitutional settlementcultural systemcultural system modelcultural system patternscultural-systemiccyberneticdonnian
Noun(11 words)
computing infrastructurecomputing operationcomputing processingconstitutional courtconstitutional powercriminal-justice systemscultural system changescultural system theorycultural systemsdiocesansearth system modeling
Choosing the right synonym
- Closest matches in this entry: acaricide, agricultural ecosystem balance, agricultural systems, anthelmintic, antibiotic.
- Sentence evidence is available for systemic, so synonym choice can be checked against real usage rather than a flat word list.
- Ranking signals come from moby, derived_reverse, opengloss.
Synonym selection checklist
- Match the part of speech before comparing meanings.
- Check whether the synonym changes intensity, formality, or emotional tone.
- Read the replacement inside the full sentence, not just beside "systemic".
- Prefer the clearest word over the most unusual word when writing for speed or comprehension.
When not to replace "systemic"
Keep "systemic" when the sentence already sounds natural, when a synonym would add unintended emphasis, or when readers need the most familiar wording. A synonym should clarify or sharpen the message, not simply make the sentence look more varied.
If two options seem close, choose the one that best matches the audience and purpose of the sentence.
Replacement workflow
1. Preserve meaning
Choose a synonym only if it keeps the core idea of "systemic" intact in the sentence you are editing.
2. Tune tone
Check whether the replacement sounds more formal, casual, emotional, technical, or forceful than the original word.
3. Re-read context
Read the full sentence after the swap. Keep the synonym only when the sentence becomes clearer or more precise.
Review note: Synonym lists are ranked with lexical data and reviewed for practical writing value. Use the comparison notes, sentence evidence, and source labels together; a high-ranking synonym can still be wrong when the audience, register, or grammar changes.
Final fit check
After choosing a replacement for "systemic", read the sentence once for meaning and once for rhythm. The best synonym should feel natural in the full sentence, not only accurate in a word list.
If the synonym makes the sentence slower, vaguer, or more dramatic than intended, keep "systemic" or choose a simpler alternative from the closest-match group.
Related word relations
OpenGloss and ConceptNet supply richer edges like generalizations, collocations, and derivations.
More general
4 entriesMore specific
5 entriessystemic biassystemic changesystemic diseasesystemic infectionsystemic toxicity
Collocations
5 entriessystemic approachsystemic changesystemic diseasesystemic risksystemic thinking
Inflections
2 entriesmore systemicmost systemic
Derivations
1 entriessimilar
1 entriesSample sentences
12 total sentences available.
Poverty is a systemic problem.
Source: tatoeba (5816202)
“A lot of times people don't believe people in isolation, but when you hear repeated stories that's when you begin to think these are systemic problems that we need to deal with. And that's powerful.”
Source: tatoeba (8257491)
The European crisis is a systemic problem, which can only be solved through common action of all EU states.
Source: tatoeba (9080616)
Showing 4 of 12 available sentences.
Common questions
What are the closest synonyms for "systemic"?
Closest matches include acaricide, agricultural ecosystem balance, agricultural systems, anthelmintic, antibiotic.
How should I check whether a synonym fits "systemic"?
Compare the replacement against real sentence context. This entry includes sample sentences so you can check tone, grammar, and meaning before swapping words.