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Keep "weltschmerz" when the sentence already sounds natural, when a synonym would add unintended emphasis, or when readers need the most familiar wording. A synonym should clarify or sharpen the message, not simply make the sentence look more varied.
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Review note: Synonym lists are ranked with lexical data and reviewed for practical writing value. Use the comparison notes, sentence evidence, and source labels together; a high-ranking synonym can still be wrong when the audience, register, or grammar changes.
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11 total sentences available.
And in this respect [Ludwig] Uhland presents a marked and useful contrast to the lackadaisical, sentimental, Weltschmerz school, the poets of which trade on their own pretended misery, and, cunningly enough, suggest that their poems must be touching and true in proportion as the authors set themselves forth as peculiarly skilled in bitterness of heart and badness of life.
Source: wiktionary
[page 118] It speaks well for the general healthiness of the English nation that we have no words corresponding to ‘Weltschmerz’ or ‘Ennui’. The ordinary Englishman experiences neither of these things. […] [page 119] Weltschmerz is a species of disease, a sort of spiritual measles—or to give a more technical diagnosis, it is the revolt of a young soul against the stone and iron of existence. […] ‘Ennui’ only attacks people either of hopeless incapacity or incurable laziness. Weltschmerz on the other hand is a positive, restless, state, a state of protest against the nature of things.
Source: wiktionary
The artificial woe of the ancient armorist, whose days were a perpetual honeyed despair and his nights one long lachrymose vigil, is an extinct literary tradition; but a new, a different, and, alas! a more real sadness has taken its place—the modern world-sadness, the Weltschmerz, which infects all we do and are, not excepting our love-making— […]
Source: wiktionary
Here we have it at once, blended though it may be with the new elements of purging humour and all-embracing Weltschmerz, in [William] Shakespeare's Hamlet.
Source: wiktionary
Showing 4 of 11 available sentences.
Closest matches include world-weariness.
Compare the replacement against real sentence context. This entry includes sample sentences so you can check tone, grammar, and meaning before swapping words.