Careworn

He had grown thin and careworn, and had lost the loud, cheery manner for which he had been remarkable.

Source: tatoeba (6981729)

The weeks of working hard to look after his sick family left him looking careworn.

Source: wiktionary

At length the long-expected knock was heard. She hurried to the door, and met her husband; a man whose face was care-worn and depressed, though he was young. There was a remarkable expression in it now; a kind of serious delight of which he felt ashamed, and which he struggled to repress.

Source: wiktionary

The effect upon his personal appearance of this wear and tear of his intellect was striking and manifest. The hue of youth and health entirely departed from his cheeks, and he looked so sad and careworn, that it was quite a terrible thing to look upon a young lad so, as it were, upon the threshold of existence, and in whom anxious thoughts were making such war upon the physical energies.

Source: wiktionary