Systemic and local hygiene has supplanted drugs and surgery in the treatment of diseases of the anus, rectum, sigmoid flexure, and vermiform appendix.
Source: tatoeba (11034139)
Ranked by relevance and common usage.
Keep "flexure" when the sentence already sounds natural, when a synonym would add unintended emphasis, or when readers need the most familiar wording. A synonym should clarify or sharpen the message, not simply make the sentence look more varied.
If two options seem close, choose the one that best matches the audience and purpose of the sentence.
Choose a synonym only if it keeps the core idea of "flexure" intact in the sentence you are editing.
Check whether the replacement sounds more formal, casual, emotional, technical, or forceful than the original word.
Read the full sentence after the swap. Keep the synonym only when the sentence becomes clearer or more precise.
Review note: Synonym lists are ranked with lexical data and reviewed for practical writing value. Use the comparison notes, sentence evidence, and source labels together; a high-ranking synonym can still be wrong when the audience, register, or grammar changes.
After choosing a replacement for "flexure", read the sentence once for meaning and once for rhythm. The best synonym should feel natural in the full sentence, not only accurate in a word list.
If the synonym makes the sentence slower, vaguer, or more dramatic than intended, keep "flexure" or choose a simpler alternative from the closest-match group.
OpenGloss and ConceptNet supply richer edges like generalizations, collocations, and derivations.
4 total sentences available.
Systemic and local hygiene has supplanted drugs and surgery in the treatment of diseases of the anus, rectum, sigmoid flexure, and vermiform appendix.
Source: tatoeba (11034139)
but scarce had I drawn back mine arms, strained the outward flexure of my knee-joints, and was fixed in an apt disposure to take the corvetto primo and leap-valiant of the cour, when methought suddenly there came in and did appear before me mine ancient, most reverend and singular good friend, the rector of Saynt Andrew of S—, nearest in neighbourhood, but not of mine own cure, myself being of D— manor house in the same vicinage,—who astonished beyond measure at my so extasied gladness, demanded wherefore I did carry myself on this wise?
Source: wiktionary
varying with the flexures of the valley through which it meandered
Source: wiktionary
The Stomach [of a weasel] about three inches long; proportionably, more than a Dogs. An inch in Diametre at the upper Orifice; and the nether, ¼; having a flexure towards its Conjunction with the Guts: ſhaped like to the body of a pair of Bag-Pipes.
Source: wiktionary
Closest matches include bend, fold, angle, angularity, angularness.
Compare the replacement against real sentence context. This entry includes sample sentences so you can check tone, grammar, and meaning before swapping words.