Folio

The play Macbeth first appeared in Shakespeare's First Folio of 1623.

Source: tatoeba (13598754)

The missing folio caused uncertainty about the manuscript's original structure.

Source: tatoeba (13598757)

[Thomas] Hood also presented his treatises in such a way that conveniently accessing specific lessons was difficult, if not impossible, for the reader-practitioner. For example, his book entitled The Vse of Both the Globes, Celestiall and Terrestriall... (1592) was roughly two hundred pages long but did not include such helpful tools as an index, a table of contents, or even folio numbers. In order to refer to some lesson that he might need, the reader would have to leaf through the text until the passage in question was found, or else rely upon his own marginal notes.

Source: wiktionary

We saw above that the fourth quire consists of ten folios, two of which (folios 29 and 31) Richer added to a quaternion (folios 23 to 28, 30, 32). Most of the folios Richer added to his manuscript supplement, elaborate, or amend text that he had already composed in the codex. In this quire, however, Richer wrote around the added folios as if it was the quire he added to them, not the converse. Indeed, if we were to remove folios 29 and 31, there would be neither grammatical nor narrative continuity between the original folios of the quire which would face each other, that is, between folios 28^(v[erso]) and 30^(r[ecto]) on the one hand, or folios 30ᵛ and 32ʳ on the other.

Source: wiktionary